Richter's syndrome with identification of marker chromosomes

Autor:	J. W. Hamer, Christine M. McEwan, Peter H. Fitzgerald, M. E. J. Beard
Rok vydání:	1980
Předmět:	Genetics Cancer Research Marker chromosome Aneuploidy Chromosome Karyotype Biology medicine.disease Oncology Chromosome instability medicine Ploidy Chromosome 21 Small supernumerary marker chromosome
Zdroj:	Cancer. 46:135-138
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(19800701)46:1<135::aid-cncr2820460121>3.0.co;2-n
Popis:	A case is presented of a man with Richter's syndrome with diffuse histiocytic lymphoma following a ten-year history of untreated chronic lymphatic leukemia. He did not respond to therapy. The lymphoma cells had 61 chromosomes with aneuploidy of 13 chromosomes and 11 structurally altered chromosomes. Only chromosomes 8, 9, 12, 14, and 18 were diploid and without abnormality. Significantly, part of chromsome 1q was duplicated as in the partial trisomy of 1q reported to characterize a number of hematologic neoplasms. A large marker chromosome with subterminal centromere was a tandem duplication of chromosome 4q.
Databáze:	OpenAIRE
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