CD22 serves as a receptor for soluble IgM

Autor:	Yasunori Kozutsumi, Manabu Fujimoto, Takahiro Adachi, Satoru Harumiya, Thomas F. Tedder, Matthias Wabl, Hiromu Takematsu
Rok vydání:	2011
Předmět:	Glycan biology Ligand Immunology CD22 breakpoint cluster region Fc receptor Lectin Molecular biology Sialic acid chemistry.chemical_compound chemistry immune system diseases hemic and lymphatic diseases biology.protein Immunology and Allergy Receptor
Zdroj:	European Journal of Immunology. 42:241-247
ISSN:	0014-2980
DOI:	10.1002/eji.201141899
Popis:	CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).
Databáze:	OpenAIRE
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