Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats
| Autor: | Mahsan Akbarian, Somaieh Ahmadabady, Kataneh Abrari, Sabiheh Amirahmadi, Mahmoud Hosseini, Farzaneh Vafaee, Arezoo Rajabian |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Aché Morris water navigation task medicine.disease_cause Biochemistry Superoxide dismutase Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Cognitive decline biology business.industry Malondialdehyde Acetylcholinesterase language.human_language Endocrinology chemistry language biology.protein Neurology (clinical) Propylthiouracil business hormones hormone substitutes and hormone antagonists Oxidative stress medicine.drug |
| Zdroj: | Metabolic Brain Disease. 36:2393-2403 |
| ISSN: | 1573-7365 0885-7490 |
| Popis: | Hypothyroidism has been reported to be associated with cognitive decline. Considering the role of folic acid (FA) in cognitive performance, the present study was designed to investigate the effects of FA on hypothyroidism-induced cognitive impairment, oxidative damage, and alterations in acetylcholinesterase (AChE) activity in rat model of propylthiouracil (PTU)-induced hypothyroidism. In this study, PTU (0.05% in drinking water) and FA (5, 10, and 15 mg/kg, oral gavage) were administered for the rats during 7 weeks. Then, behavioral performance was tested using Morris water maze (MWM) and passive avoidance (PA) tasks. Finally, oxidative stress indicators and AChE activity were assayed in the brain tissues. The impairing effect of hypothyroidism on cognitive performance was markedly alleviated by FA especially at higher doses. In the MWM test, FA reduced escape latency and travelled distance, compared to the non-treated hypothyroid group. In the PA test, latency to enter dark chamber was significantly enhanced by FA compared to the non-treated hypothyroid group (p |
| Databáze: | OpenAIRE |
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