RETRACTED ARTICLE: Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma

Autor:	Koroosh Ahmadi, Mohsen Mohammadi, Hamid Yahaghi, Omid Rahmani, Hamid Reza Safaei, Ayoob Rostamzadeh, Omar Ghaderi
Rok vydání:	2015
Předmět:	Oncology Univariate analysis Pathology medicine.medical_specialty Multivariate analysis business.industry General Medicine medicine.disease Independent predictor Text mining Renal cell carcinoma Internal medicine medicine Immunohistochemistry Clinical significance Stage (cooking) business
Zdroj:	Tumor Biology. 37:7583-7587
ISSN:	1423-0380 1010-4283
DOI:	10.1007/s13277-015-4652-z
Popis:	In order to evaluate the correlation of B7-H4 and B7-H1 with renal cell carcinoma (RCC), we analyzed B7-H1 and B7-H4 expressions and their clinical significance by immunohistochemical method. Our result indicated that B7-H4-positive staining was detected in 58.13 % of RCC tissues (25 tissues tumors), and there were 18 tissues of patients without detectable B7-H4. Furthermore, 21 cases (48.83 %) were B7-H1-positive. Positive tumor expressions of B7-H4 and B7-H1 were markedly related to advanced TNM stage (P = 0.001; P = 0.014), high grade (P = 0.001; P = 002), and larger tumor size (P = 0.002; P = 024) in RCC tissues than patients with B7-H4-negative and B7-H1-negative in RCC tissues. The patients with B7-H1 and B7-H4-positive expressions were found to be markedly correlated with the overall survival of the patients (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2ae19a749428cd8b53011a693b2f57c7 https://doi.org/10.1007/s13277-015-4652-z Zobrazit plný text záznamu Full text from SpringerLink