Systematic Investigation of the Thermodynamics of HSA Adsorption to N-iso-Propylacrylamide/N-tert-Butylacrylamide Copolymer Nanoparticles. Effects of Particle Size and Hydrophobicity

Autor:	Sara Linse, Stina Lindman, Iseult Lynch, Kenneth A. Dawson, Eva Thulin, Hanna Nilsson
Rok vydání:	2007
Předmět:	Materials science Mechanical Engineering Enthalpy Nanoparticle Bioengineering General Chemistry Condensed Matter Physics chemistry.chemical_compound Adsorption Monomer Chemical engineering chemistry Polymer chemistry Copolymer General Materials Science Particle size Stoichiometry Macromolecule
Zdroj:	Nano Letters. 7:914-920
ISSN:	1530-6992 1530-6984
DOI:	10.1021/nl062743+
Popis:	Nanoparticles in biological fluids almost invariably become coated with proteins that may confer nanomedical and nanotoxicological effects. Understanding these effects requires quantitative measurements using simple systems. Adsorption of HSA to copolymer nanoparticles of varying hydrophobicity and curvature was studied using ITC, yielding stoichiometry, affinity, and enthalpy changes upon binding. The hydrophobicity was controlled via the co-monomer ratio, N-iso-propylacrylamide/N-tert-butylacrylamide. The most hydrophobic particles become fully covered with a single layer of protein, except at high curvature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2adbe19484c7904601daef5c187c2c2f https://doi.org/10.1021/nl062743+ Zobrazit plný text záznamu