Half-sandwich (Cp*)RhCl 2 core complexes containing sulfur donor thiosemicarbazones: Synthesis, cytotoxic activity and human serum albumin binding studies
| Autor: | Qi Xiao, Peng Binghua, Peiyuan Li, Wei Su, Shan Huang, Jiangning Xie, Yuchun Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry biology.organism_classification Human serum albumin 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences Rhodium Inorganic Chemistry HeLa chemistry.chemical_compound chemistry Cell culture Materials Chemistry medicine Molecule Curcuminoid Physical and Theoretical Chemistry Selectivity medicine.drug |
| Zdroj: | Journal of Organometallic Chemistry. 868:24-30 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2018.04.037 |
| Popis: | A series of organometallic rhodium complexes with curcuminoid ligands (1−9) have been synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structure of complex 9 has been characterized by X-ray crystallography. The in vitro activities of all the compounds have been evaluated against the HeLa, HepG2, CNE-2, SGC-7901, KB human cancer cell lines and HEK-293 T human healthy cell lines. The rhodium complex 6 exhibits excellent cytotoxic effect and promising selectivity towards cancer cell lines. Furthermore, the binding efficacy of complex 6 with HSA has been assessed using fluorescence spectroscopic tools. |
| Databáze: | OpenAIRE |
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