Amphiphilic Poly(l-lysine-b-caprolactone) Block Copolymers: Synthesis, Characterization, and Solution Properties

Autor:	Dhanjay Jhurry, Helmut Ritter, Shaheen Motala-Timol, Gaytree Mohun, Jiawen Zhou, Archana Bhaw-Luximon
Rok vydání:	2008
Předmět:	Aqueous solution Polymers and Plastics Chemistry Organic Chemistry complex mixtures Ring-opening polymerization Allylamine Inorganic Chemistry chemistry.chemical_compound Polymerization Polycaprolactone Polymer chemistry Amphiphile Materials Chemistry Copolymer bacteria Caprolactone
Zdroj:	Macromolecules. 41:5571-5576
ISSN:	1520-5835 0024-9297
DOI:	10.1021/ma800917c
Popis:	We report on the synthesis of poly(l-lysine-b-caprolactone) block copolymers via an original and elegant approach whereby Z-l-lysine is first polymerized in the presence of allylamine and the resulting amino-terminated poly(Z-l-lysine) is then used in situ as macroinitiator for the polymerization of e-caprolactone in the presence of tin(II) octanoate as catalyst. A range of poly(ester-b-peptide)s were obtained by varying the ratio of polypeptide to polycaprolactone units. After removal of the Z group of l-lysine units, the copolymers were soluble in water and their solution behavior was examined. They spontaneously form micelle-like objects in solution with sizes around 10 and 70 nm depending on the block lengths of the hydrophilic and hydrophobic sequences. The smaller size particles would adopt a core−shell morphology while the larger particles would be more in line with a vesicle morphology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2acb4e6f2499b9240457088d5a73b702 https://doi.org/10.1021/ma800917c Zobrazit plný text záznamu