α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II)

Autor:	Peter K. S. Siegl, Salah D. Kivlighn, Gloria J. Zingaro, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, William J. Greenlee, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Raymond S.L. Chang
Rok vydání:	1995
Předmět:	Angiotensin II receptor type 1 Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Angiotensin II Receptor subtype Drug Discovery Molecular Medicine Potency Receptor Molecular Biology hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1151-1154
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00185-v
Popis:	Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT 1 -selective AII antagonists. Substitution in the central aromatic ring significantly increases AT 2 receptor affinity such that the n -propyl derivative 7g displayed low nanomolar potency at both AT 1 and AT 2 receptor subtypes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2ac6208c532d72a61e408771fa3545d7 https://doi.org/10.1016/0960-894x(95)00185-v Zobrazit plný text záznamu Full Text from ScienceDirect