Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
| Autor: | Griselda Didoli, Natalia Santucci, María Luisa Bay, Luis J. Nannini, Luciano D’Attilio, Cristina Bogue, Oscar Bottasso, Hugo O. Besedovsky, Susana Lioi, Ariana Díaz, Bettina Bongiovanni, Adriana del Rey, Walter Gardeñez |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Tuberculosis biology business.industry General Neuroscience C-reactive protein Dehydroepiandrosterone medicine.disease General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine chemistry.chemical_compound Endocrinology Immune system Dehydroepiandrosterone sulfate History and Philosophy of Science chemistry Internal medicine biology.protein Medicine Endocrine system business hormones hormone substitutes and hormone antagonists Hydrocortisone medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 1262:10-15 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2012.06643.x |
| Popis: | We evaluated immune and endocrine status following antituberculosis treatment in HIV-negative patients with newly diagnosed tuberculosis (TB). Treatment led to a decrease in IL-6, IL-1β, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after 4 months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after 4 months and started to decline after 6 months of treatment, reaching levels below those detected at inclusion. In contrast, in most patients, dehydroepiandrosterone sulfate (DHEAS) levels remained unchanged, although a trend toward increased concentrations was observed in a few cases 3 months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects. |
| Databáze: | OpenAIRE |
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