| Popis: |
This chapter covers the different signaling pathways affecting embryonic stem (ES) cells. We discuss those signals governing maintenance of pluripotency, survival and proliferation, and induction of differentiation. We also cover the differences in signaling responsiveness and requirements between mouse and human ES cells, and discuss the developmental context of pluripotent tissue, which gives useful insights for the derivation and culture of ES cells as well as for directed differentiation to adult tissues. |
