Enantioselective Construction of Si-Stereogenic Linear Alkenylhy-drosilanes via Copper-Catalyzed Anti-Markovnikov Hydrosilyla-tion of Alkynes
| Autor: | Yun-He Xu, Jian-Lin Xu, Zi-Lu Wang, Jinbo Zhao |
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| Rok vydání: | 2022 |
| DOI: | 10.21203/rs.3.rs-2324096/v1 |
| Popis: | Herein we report an unprecedented copper-catalyzed asymmetric anti-Markovnikov hydrosilylation of alkynes with dihydrosilanes for the synthesis of silicon-stereogenic alkenyl silanes in good regio- and enantioselectivities. Demonstrated by a diverse collection of substrates, the process grants access to chiral alkenylhydrosilanes with a simple Cu/(S)-Tol-BINAP catalytic system. The origin of the enantiocontrol was investigated by density functional theory (DFT) calculations, which revealed a quite complicated scenario involving multiple pairs of diastereomeric transition structures accounting for the high enantiocontrol under the seemingly simple conditions. |
| Databáze: | OpenAIRE |
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