| Popis: |
Hereditary cerebral hemorrhage with amyloidosis—Dutch type (HCHWA-D) is an autosomal dominant disease, characterized by recurrent cerebral hemorrhages and dementia, occurring at a relatively young age. The symptoms are caused by extensive deposition of amyloid in cerebral arterioles and leptomeningeal arteries. A point-mutation in the β-protein precursor gene on chromosome 21 is the underlying cause of the disease. In this chapter the clinical, radiological, pathological and genetic features of this disease will be summarized, with special attention for the relation between HCHWA-D and Alzheimer’s disease, which is also characterized by β-protein deposition. |
