Injectable Self-Assembling Peptide Hydrogels for Tissue Writing and Embryonic Stem Cell Culture
| Autor: | Anthony Chirayath, Sugosh Anur, Peter K. Nguyen, Adithya Kannan, Eun Jung Lee, Biplab Sarkar, Vivek A. Kumar, Pamela Hitscherich |
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| Rok vydání: | 2018 |
| Předmět: |
Chemistry
Tissue replacement Spatially resolved technology industry and agriculture Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Embryonic stem cell 0104 chemical sciences Cell biology Extracellular matrix In vivo Self-healing hydrogels Extracellular General Materials Science 0210 nano-technology Self-assembling peptide |
| Zdroj: | Journal of Biomedical Nanotechnology. 14:802-807 |
| ISSN: | 1550-7033 |
| DOI: | 10.1166/jbn.2018.2583 |
| Popis: | The fabrication of extracellular matrix-mimic hydrogels that can nurture and direct differentiation of embryonic stem cells is an important target for pattern-printed tissue replacement. Another desirable feature for such materials is their ability to be injected and recover their rheological features post-injection, allowing for facile non-invasive implantation. In this report, we demonstrate the ability of a self-assembling peptide hydrogel to support the culture of embryonic stem cells with the potential to direct differentiation. We also show that we can write a functional tissue replacement with a predetermined pattern using our formulation. Our results may lead to in vivo replacement of diseased tissue with a spatially resolved pattern of a regenerative hydrogel. |
| Databáze: | OpenAIRE |
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