New Chemovariety ofLippia albaFrom Colombia: Compositional Analysis of the Volatile Secondary Metabolites and Somein vitroBiological Activities of the Essential Oil From Plant Leaves
| Autor: | Yurina Sh. De Moya, Amner Muñoz-Acevedo, Juan D. Rodríguez, María del Carmen González |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Plant Science General Medicine biology.organism_classification 01 natural sciences 0104 chemical sciences law.invention 010404 medicinal & biomolecular chemistry Complementary and alternative medicine law Chemical diversity Drug Discovery Botany Composition (visual arts) Lippia alba Essential oil |
| Zdroj: | Natural Product Communications. 14:1934578X1986290 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | Lippia alba is a plant widely studied due to both chemical diversity and bioactivities related to its ethnobotanical uses. In this work, the composition of the volatile secondary metabolites (volatile fractions/essential oil, EO) of the flower/leaves of L. alba (from northern region of Colombia) was determined by solid phase micro-extraction/distillation-solvent extraction/microwave-hydrodistillation/gas chromatography-mass spectrometry (MWHD/GC-MS), along with some in vitro biological properties (cytotoxicity and acetylcholinesterase enzyme [AChe] inhibition) from leaf EO. Outstanding results were found: (i) cis-piperitone oxide (~13%-46%), germacrene D (~11%-30%), and limonene (~10%-22%) characterized the volatile secondary metabolites from different parts of the plant; (ii) leaf EO showed a moderate hemolytic activity (HC50: 580 ± 1 µg/mL), a significant cytotoxicity on lymphocytes (LC50: 127 ± 3 µg/mL), a high cytotoxicity on HEp2 cell line (LC50: 38 ± 2 µg/mL), and a moderate inhibitory effect on AChE (IC50: 28 ± 2 µg/mL). Based on these results, a new chemovar of L. alba is reported (represented by cis-piperitone oxide) along with its promising cytotoxic and AChE inhibiting properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|