Chronobiological Dimensions of an Olfactory Bulbectomized Rodent Animal Model for Agitated Depression

Autor:	Bernard Possidente, Catherine Pratt, Chad Page, Marilyn Y. McGinnis, Augustus R. Lumia
Rok vydání:	2000
Předmět:	medicine.medical_specialty Rodent biology Physiology Biological clock Serotonin metabolism Animal model Sexual behavior Physiology (medical) biology.animal medicine Psychiatry Neuroscience Ecology Evolution Behavior and Systematics Depression (differential diagnoses)
Zdroj:	Biological Rhythm Research. 31:416-434
ISSN:	1744-4179 0929-1016
DOI:	10.1076/0929-1016(200007)31:3;1-k;ft416
Popis:	Olfactory bulbectomized (OBX) rodents mimic some behavioral and biochemical features of chronic agitated hyposerotonergic depression. These effects of OBX include increased activity levels, altered serotonin metabolism, changes in sexual behavior, and elevated corticosteroid levels. Here we summarize published research demonstrating chronobiological changes in OBX rodents, and present new data addressing effects of OBX on additional elements of biological clock function. The chronobiological consequences of OBX make this model useful for testing hypotheses about possible causal relationships between variation in biological clock function and variation in behavioral and biochemical traits associated with clinical depression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2aa7fc4729f235166738e59b90d1ec83 https://doi.org/10.1076/0929-1016(200007)31:3 Zobrazit plný text záznamu