Glutathione as a Marker for Human Disease
| Autor: | Vishwanath Venketaraman, Mariana Lucero, Ruoqiong Cao, Brittanie Robinson, Rachel Abrahem, Erik Paredes, Andrew Martinez, Garrett Teskey, Hicret Islamoglu, Karo Gyurjian, Oscar Salaiz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tuberculosis Antioxidant business.industry medicine.medical_treatment Cancer Glutathione medicine.disease Bioinformatics 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Human disease chemistry Ageing Diabetes mellitus Medicine business Pathological |
| DOI: | 10.1016/bs.acc.2018.07.004 |
| Popis: | Glutathione (GSH), often referred to as “the master antioxidant,” participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of pathological conditions including tuberculosis (TB), HIV, diabetes, cancer, and aging. Consequently, it is not surprising that GSH has attracted the attention of biological researchers and pharmacologists alike as a possible target for medical intervention. Here, we discuss the role GSH plays amongst these pathological conditions to illuminate how it can be used as a marker for human disease. |
| Databáze: | OpenAIRE |
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