Self-Assembly of Escherichia coli Phage Shock Protein A

Autor:	Ali Tavassoli, Petra C. F. Oyston, Abigail L. Male
Rok vydání:	2014
Předmět:	biology Operon Chemistry Membrane stress General Medicine Bioinformatics medicine.disease_cause Cell biology Fight-or-flight response Transcription (biology) biology.protein medicine Self-assembly Protein A Phage shock Escherichia coli
Zdroj:	Advances in Microbiology. :353-359
ISSN:	2165-3410 2165-3402
Popis:	The Phage shock protein (Psp) response is an extracytoplasmic stress response. The central component of this system is PspA, a protein that mediates the physiological response to membrane stress. PspA is also involved in regulating its own transcription and that of the psp operon, forming a positive feedback loop. PspA has been previously shown to oligomerise into higher-order species, including a 36-meric species with ring-like structure. In this study, we demonstrate that the ring-like PspA structures further self-assemble into rod-shaped complexes. These rod-like structures may play a scaffolding role in the maintenance of membrane integrity during phage shock protein response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a8230dfae7500726435392f2cefe3b1 https://doi.org/10.4236/aim.2014.47042 Zobrazit plný text záznamu