Facile Esterification of Alcohols with 2-Acyl-4,5-dichloropyridazin-3(2H)-ones under Friedel–Crafts Conditions

Autor:	Hyo Jae Yoon, Gi Hyeon Sung, Yong-Jin Yoon, Sang Gyeong Lee, Bo Ram Kim, Ki Eun Ryu
Rok vydání:	2014
Předmět:	Green chemistry Acylation chemistry.chemical_compound chemistry Organic Chemistry Organic chemistry Friedel–Crafts reaction Tetrahydrofuran
Zdroj:	Synlett. 25:1909-1915
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0034-1378335
Popis:	This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel–Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel–Crafts conditions, representing a rapid, practical, and efficient method of esterification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a7da67eb8e72f7f4530c9173c513382 https://doi.org/10.1055/s-0034-1378335 Zobrazit plný text záznamu