Disorderly conduct in γδ versus αβ T cell lineage commitment
| Autor: | Joonsoo Kang, Kavitha Narayan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Genetics
Lineage (genetic) T cell Immunology celebrities T-cell receptor hemic and immune systems chemical and pharmacologic phenomena Biology celebrities.reason_for_arrest medicine.anatomical_structure medicine Immunology and Allergy Cytotoxic T cell Signal transduction Antigen-presenting cell Disorderly conduct CD8 |
| Zdroj: | Seminars in Immunology. 22:222-227 |
| ISSN: | 1044-5323 |
| DOI: | 10.1016/j.smim.2010.04.003 |
| Popis: | The mechanism of T cell precursor commitment to the γδ or αβ T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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