Palladium(II) and platinum(II) complexes of ((2-pyridyl)pyrazol-1-ylmethyl)benzoic acids: Synthesis, Solid state characterisation and biological cytotoxicity
| Autor: | David A. McMorran, Keith C. Gordon, Gregory I. Giles, Warrick K. C. Lo, Jonathan E. Barnsley, Aidan P. McKay, Dan Preston, James D. Crowley |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Stereochemistry Hydrogen bond chemistry.chemical_element Aromaticity 010402 general chemistry Crystal engineering 01 natural sciences Medicinal chemistry 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Materials Chemistry Molecule Chelation Physical and Theoretical Chemistry Benzene Benzoic acid Palladium |
| Zdroj: | Inorganica Chimica Acta. 446:41-53 |
| ISSN: | 0020-1693 |
| Popis: | The new ligands 3-(3-(2-pyridyl)pyrazol-1-ylmethyl)benzoic acid (L2) and 5-(3-(2-pyridyl)pyrazol-1-ylmethyl)benzene 1,3-dicarboxylic acid (L3) are reported and the synthesis and characterisation of [PdCl2(L)] and [PtCl2(L)] complexes of these and the previously reported 4-(3-(2-pyridyl)pyrazol-1-ylmethyl)benzoic acid (L1) are described. In the solid state, the square planar complexes assemble via hydrogen bonding interactions involving COOH and M–Cl groups as well as by various π-stacking interactions involving the aromatic rings on the ligands and, notably, the chelate rings. Hirshfeld surface analysis has been used to gain insight into the assembly of the molecules. Preliminary studies of the biological cytotoxicity of the [PtCl2(L)] complexes against A549 and MDA-MB-231 cancer cell lines are reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect