The effects of inhalation salbutamol administration on systemic and pulmonary hemodynamic, pulmonary mechanics and oxygen balance during general anaesthesia in the horse
Autor: | R. Kabes, M. Patschova, S. Krisova |
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Rok vydání: | 2010 |
Předmět: |
Spirometry
Cardiac output General Veterinary medicine.diagnostic_test 040301 veterinary sciences business.industry Hemodynamics 04 agricultural and veterinary sciences 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Blood pressure 030202 anesthesiology Anesthesia Heart rate Salbutamol Medicine Pulmonary shunt Arterial blood medicine.symptom business medicine.drug |
Zdroj: | Veterinární medicína. 55:445-456 |
ISSN: | 1805-9392 0375-8427 |
DOI: | 10.17221/2984-vetmed |
Popis: | This research aimed to determine the effect of aerosolized salbutamol administration on systemic and pulmonary hemodynamic, pulmonary mechanics and oxygen balance in healthy horses during general anaes - thesia. Six healthy Thoroughbreds (body weight range 471-587 kg) underwent two general anaesthesias in dorsal recumbency with and without aerosolized salbutamol administration in randomized order with a one month washout period. The anaesthesia was induced by 1.1 mg/kg of xylazine, 0.02 mg/kg of diazepam and 2.2 mg/kg of ketamine, maintained with isoflurane in oxygen and air and horses were mechanically ventilated. Measure - ment of arterial and pulmonary arterial blood pressures, cardiac output and arterial and mixed venous blood gas analysis was carried out. Spirometry was performed using a Horse-lite. After achieving a steady state, baseline (T 0 ) values of cardiac output, systemic and pulmonary arterial blood pressures, heart rate, dynamic compliance, airway resistance and arterial and mixed venous blood gas values and pH were recorded in both groups. In the S-group (salbutamol), 2 µg/kg of aerosolized salbutamol were administered synchronously with inspirium into the tracheal tube. In both groups data were recorded at 15, 30, 45 and 60 min (T 15 , T 30 , T 45 , T 60 ) after the baseline. PaO 2 /FiO 2 ratio, oxygen consumption (VO 2 ), oxygen delivery (DO 2 ), pulmonary shunt values were calculated. Data were tested for normality and compared within each group: T 0 value with T 15 , T 30 , T 45 , T 60 values using Wilcoxon's test with Bonferoni correction (significance level 0.0125). For each time point, comparisons were made between the S- and C-groups (control) using Wilcoxon's test. In the S-group, there was a significant increase in values (mean ± SD) of cardiac output (l/min), T 0 (38 ± 7), a peak at T 15 (64 ± 25.5), significantly higher values persisted throughout the period of anaesthesia; heart rate (beats/min), T 0 (32 ± 2), T 15 (40 ± 6), T 30 (38 ± 5); DO 2 found in the S-group compared to the C-group. Pulmonary arterial blood pressure was significantly lower in the S-group. Aerosolized salbutamol administration in healthy horses during general anaesthesia caused hemodynamic changes which resulted in an elevation of oxygen delivery. It can have a positive effect on arterial oxygenation, but the effect varies between individuals. |
Databáze: | OpenAIRE |
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