Microalgae-derived sterols do not reduce the bioavailability of oral vitamin D3 in mice
| Autor: | Julia Kühn, Corinna Brandsch, Mikis Kiourtzidis, Anika Nier, Simone Bieler, Bertrand Matthäus, Carola Griehl, Gabriele I. Stangl |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal for Vitamin and Nutrition Research. |
| ISSN: | 1664-2821 0300-9831 |
| DOI: | 10.1024/0300-9831/a000766 |
| Popis: | Abstract. Microalgae have drawn increasing attention as sustainable food sources, also because of their lipid-lowering phytosterols. As phytosterols are also discussed critically regarding their effect on the availability of fat-soluble vitamins, this study aimed to investigate microalgae-derived phytosterols and their effect on vitamin D status. GC–MS analysis showed large variations in the phytosterol profiles of microalgal species. The most frequent sterols were β-sitosterol and stigmasterol. To investigate their effects on vitamin D status, 40 mice were randomized to four groups and fed a vitamin D3-adequate (25 μg/kg) Western-style diet with 0% phytosterols (control) or 1% ergosterol (a fungal sterol not typical for microalgae), β-sitosterol or stigmasterol for four weeks. Contrary to the hypothesis that phytosterols adversely affect vitamin D uptake, mice fed β-sitosterol had significantly higher concentrations of vitamin D3 in plasma (3.15-fold, p3 in plasma and skin were also observed in mice fed stigmasterol. In contrast, vitamin D3 levels in the ergosterol and control groups did not differ. The increased tissue levels of vitamin D3 in mice fed β-sitosterol and stigmasterol were not attributable to the observed reduction in liver triglycerides in these groups. The data rather suggest that changes in bile acid profiles were responsible for the beneficial effect of microalgae sterols on the bioavailability of vitamin D3. In conclusion, consumption of microalgae might not adversely affect vitamin D status. |
| Databáze: | OpenAIRE |
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