ChemInform Abstract: EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3-Phosphate Mimics

Autor:	Michael J. Miller, C. Y. Han, Kenneth J. Gruys, James A. Sikorski, Ko-Chung Lin, Joel E. Ream, Paul D. Pansegrau, D. G. Cleary, Mark C. Walker, Diane Susan Braccolino, Dora M. Schnur, Jose L. Font, Susan D. Corey, Ajit S. Shah
Rok vydání:	2010
Předmět:	chemistry.chemical_classification ATP synthase biology Stereochemistry EPSP synthase General Medicine Phosphate Catalysis chemistry.chemical_compound Malonate Enzyme chemistry biology.protein Methylene
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199335301
Popis:	Novel aromatic bisubstrate inhibitors of the enzyme EPSP (5-enolpyruvoylshikimate-3-phosphate) synthase (EC 2.5.1.19) have been designed and synthesized as structural analogs of the single, catalytic intermediate 1 utilized by the enzyme. These aromatic inhibitors incorporate novel α-hydroxyphosphonates, malonate ethers and α-hydroxymalonates as replacements for the hydrolytically labile 3-phosphate group. These 3-phosphate mimics were much preferred to the corresponding methylene and vinylic phosphonates, malonates and phosphonomethyl ethers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a59aa2daa944c35ccba79382aedebaf https://doi.org/10.1002/chin.199335301 Zobrazit plný text záznamu Plný text