Study of the Interactions between Neurophysin II and Dipeptide Ligand by Means of Molecular Dynamics
| Autor: | Bogdan Lesyng, Jerzy Ciarkowski, R. Kazmierkiewicz, Cezary Czaplewski, Bernard Lammek |
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| Rok vydání: | 1995 |
| Předmět: |
Vasopressin
Dipeptide Ligand Neurophysin I Organic Chemistry Neurophysins Catalysis Computer Science Applications Inorganic Chemistry chemistry.chemical_compound medicine.anatomical_structure Computational Theory and Mathematics chemistry Oxytocin Biochemistry Posterior pituitary Neurophysin II medicine Physical and Theoretical Chemistry hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Molecular Modeling. 1:143-149 |
| ISSN: | 0948-5023 1610-2940 |
| DOI: | 10.1007/s008940050011 |
| Popis: | The nonapeptide hormones oxytocin (OT) and vasopressin (VP), while transported in the posterior pituitary, are packaged into neurosecretory granules (NSG) in the form of high associates with disulfide-rich proteins known as neurophysin I (NPI) and neurophysin II (NPII), respectively. In the NSG, neurophysins serve as carrier proteins to the hormones, until the latter are dissociated upon secretion into blood. To shed more light on molecular self-recognition between NPs, and between NPs and their ligands, we have studied their molecular association, using as a starting point the recently published solid-state structure (Cα-trace) of the neurophysin II-dipeptide complex. |
| Databáze: | OpenAIRE |
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