ChemInform Abstract: Novel Tryptophan Dioxygenase Inhibitors and Combined Tryptophan Dioxygenase/5-HT Reuptake Inhibitors

Autor:	M. Salter, H. T. Jones, R. Iyer, R. Hazelwood, D. J. Madge
Rok vydání:	2010
Předmět:	Tryptamine chemistry.chemical_compound Antidepressant therapy Biochemistry Dioxygenase Chemistry 5 ht reuptake Tryptophan General Medicine Metabolism Inhibitory postsynaptic potential Reuptake
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199635117
Popis:	Tryptophan dioxygenase (TDO) is a liver enzyme that is responsible for the majority of the metabolism of tryptophan. A series of novel 3-(2-pyridylethenyl)indoles are shown to be potent inhibitors of TDO with selected members of the series also having 5-hydroxy tryptamine (5-HT) reuptake inhibitory activity. These compounds are shown to provide significant increases in the levels of tryptophan and 5-HT in the cerebrospinal fluid and are thus of interest for antidepressant therapy.
Databáze:	OpenAIRE
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