Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats
| Autor: | Xian-Guo Liu, Yi-Wei Feng, Xiongxiong Zhong, Wei Wang, Xu-Hong Wei, Jing Xu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.disease 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Anesthesiology and Pain Medicine medicine.anatomical_structure Peripheral neuropathy Dorsal root ganglion chemistry Spinal Cord Dorsal Horn Anesthesia Neuropathic pain Methylcobalamin Hyperalgesia medicine Molecular Medicine Sciatic nerve medicine.symptom 030217 neurology & neurosurgery Nicotinamide adenine dinucleotide phosphate medicine.drug |
| Zdroj: | Molecular Pain. 12:174480691665708 |
| ISSN: | 1744-8069 |
| DOI: | 10.1177/1744806916657089 |
| Popis: | BackgroundVincristine, a widely used chemotherapeutic agent, often induces painful peripheral neuropathy and there are currently no effective drugs to prevent or treat this side effect. Previous studies have shown that methylcobalamin has potential analgesic effect in diabetic and chronic compression of dorsal root ganglion model; however, whether methylcobalamin has effect on vincristine-induced painful peripheral neuropathy is still unknown.ResultsWe found that vincristine-induced mechanical allodynia and thermal hyperalgesia, accompanied by a significant loss of intraepidermal nerve fibers in the plantar hind paw skin and an increase in the incidence of atypical mitochondria in the sciatic nerve. Moreover, in the spinal dorsal horn, the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the protein expression of p-p65 as well as tumor necrosis factor α was increased, whereas the protein expression of IL-10 was decreased following vincristine treatment. Furthermore, intraperiton... |
| Databáze: | OpenAIRE |
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