A multi-center study to evaluate the pharmacokinetic and clinical interactions between alprazolam and imipramine

Autor:	Thaddeus H. Grasela, Barbara G. Wells, Edward J. Antal, Randall B. Smith, Larry Ereshefsky, R. Lee Evans
Rok vydání:	1991
Předmět:	education.field_of_study business.industry Population Pharmacology Imipramine Pharmacokinetic analysis Alprazolam Pharmacokinetics Pharmacodynamics Multi center study Desipramine medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics business education medicine.drug
Zdroj:	Journal of Pharmacokinetics and Biopharmaceutics. 19:S93-S100
ISSN:	0090-466X
Popis:	The results of this study document the safety of co-administering alprazolam at doses up to 4 mg per day to patients already receiving imipramine. Although a pharmacokinetic interaction was observed by both a traditional analysis approach and a population analysis approach resulting in a significant increase in imipramine and desipramine plasma concentrations, no adverse pharmacodynamic effects were found in behavioral measurements or the incidence and severity of side effects. The ability of population pharmacokinetic analysis to provide insight in interpreting the results obtained from the traditional pharmacokinetic evaluation provide further support for the use of performing population pharmacokinetic analysis of data collected during clinical studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a3447f55e59cd63cd25e83074ce1b00 https://doi.org/10.1007/bf01371011 Zobrazit plný text záznamu Full text from SpringerLink