ChemInform Abstract: Selenosartans: Novel Selenophene Analogues of Milfasartan and Eprosartan

Autor:	Rebecca L. Grange, Andrea J. North, James Ziogas, James A. Angus, Carl H. Schiesser
Rok vydání:	2008
Předmět:	medicine.drug_class Stereochemistry chemistry.chemical_element Eprosartan General Medicine Receptor-mediated endocytosis Receptor antagonist chemistry.chemical_compound chemistry medicine Thiophene MILFASARTAN Receptor Selenium medicine.drug
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200827215
Popis:	A series of selenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT 1 receptor antagonist properties. All four selenophene compounds proved to be potent AT 1 receptor antagonists, with pK B estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT 1 receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a3220b4ad03d4e82d1948f690913688 https://doi.org/10.1002/chin.200827215 Zobrazit plný text záznamu Plný text