Pd/light-induced alkyl–alkenyl coupling reaction between unactivated alkyl iodides and alkenylboronic acids
| Autor: | Ilhyong Ryu, Yen-Ku Wu, Yi Ting Wang, Hsin Ju Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Addition reaction Double bond 010405 organic chemistry Chemistry Radical Organic Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Coupling reaction 0104 chemical sciences Catalysis Reaction rate constant Heck reaction lipids (amino acids peptides and proteins) Alkyl |
| Zdroj: | Organic Chemistry Frontiers. 7:1266-1270 |
| ISSN: | 2052-4129 |
| DOI: | 10.1039/d0qo00318b |
| Popis: | Alkyl–alkenyl coupling reaction between unactivated alkyl iodides and 2-arylalkenylboronic acids utilizing a Pd/light combined system was studied. This reaction provided 2-alkylarylalkenes in good yields. It is proposed that in this reaction alkyl radicals are formed by SET from a Pd catalyst to alkyl iodides, which then undergo addition reactions to form C–C double bonds of alkenyl boronic acids and the subsequent β-fragmentation of boronyl radicals leads to the formation of alkyl-substituted arylalkenes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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