Preparation of two dinor-PGI2 metabolites from 6-keto-PGF1α by
| Autor: | Lincoln Frank H, Oldrich K. Sebek, Frank F. Sun, Bruce M. Taylor |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
chemistry.chemical_classification
biology Chemistry Metabolite Prostaglandin Dehydrogenase Prostacyclin Reductase biology.organism_classification Biochemistry Transformation (genetics) chemistry.chemical_compound Endocrinology Enzyme medicine lipids (amino acids peptides and proteins) medicine.drug Mycobacterium |
| Zdroj: | Prostaglandins. 20:729-733 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(80)90111-2 |
| Popis: | The transformation of 6-keto-PGF1α to two prostacyclin metabolites, 2,3-dinor-6-keto-PGF1α (I) and 2,3-dinor-6,15-diketo-13,14-dihydro-PGF1α (II) by Mycobacterium rhodochrous UC-6176 is described. The finding that the bacterium oxidized 6-keto-PGF1α to the 6,15-diketo metabolite II shows that it contains 15-hydroxy prostaglandin dehydrogenase and Δ13 reductase enzyme systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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