Design, synthesis and antifungal activity of novel triazole derivatives

Autor:	Honggang Hu, Qing Jie Zhao, Qiu Ye Wu, Shi Chong Yu, Yan Song
Rok vydání:	2007
Předmět:	Antifungal biology medicine.drug_class Stereochemistry Lanosterol Active site General Chemistry chemistry.chemical_compound Design synthesis chemistry medicine biology.protein Triazole derivatives Fluconazole medicine.drug
Zdroj:	Chinese Chemical Letters. 18:670-672
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2007.04.019
Popis:	Twenty-three 1-(1H-1, 2, 4-thazole-1-yl)-2-(2, 4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase. In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a0c078e95fd86341b377e6dfa2939ff https://doi.org/10.1016/j.cclet.2007.04.019 Zobrazit plný text záznamu Full Text from ScienceDirect