Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles

Autor:	T. M. Mitina, Alexander A. Spasov, I. E. Tolpygin, K. V. Lenskaya, N. A. Kolobrodova, D. S. Yakovlev, V. A. Kosolapov, M. P. Voronkova, L. V. Naumenko, O. A. Salaznikova, L. V. El’tsova, V. A. Anisimova, N. A. Gurova
Rok vydání:	2012
Předmět:	Pharmacology Benzimidazole chemistry.chemical_compound Chemistry Drug Discovery Pharmacology toxicology Chlorine atom Nucleophilic substitution Antagonist Biological activity Combinatorial chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 46:325-330
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-012-0791-3
Popis:	The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT2 antagonist activity; platelet antiaggregant properties; and moderate P2Y1-antagonist, antiarrhythmic, and hypoglycemic action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2a01521cacc002c1206f535986728d8b https://doi.org/10.1007/s11094-012-0791-3 Zobrazit plný text záznamu Plný text ve formátu PDF