| Autor: |
Katalin Pálóczi, Ferenc Várnai, George Füst, J. G. Szelenyi, Dénes Bánhegyi, Susan R. Hollán, H. Wachter, János Szabó, G. A. Medgyesi, Eszter Ujhelyi, Gábor Illei, Dietmar Fuchs, Leandro Medrano, Lajos István, Attila Horváth |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
Transfusion Science. 11:73-78 |
| ISSN: |
0955-3886 |
| DOI: |
10.1016/0955-3886(90)90012-8 |
| Popis: |
Before the introduction of obligatory blood donor screening for HIV-antibodies in Hungary (July 1, 1986) a male homosexual blood donor infected three recipients; two of them in turn infected their spouses. The donor exhibited no HIV-associated symptoms and his permanent homosexual partner remained seronegative and PCR negative. By contrast, two of the three recipients died of AIDS and in longitudinal immunological surveillance the immune parameters of the recipients and even their spouses was found to be much worse than that of the donor. These findings suggest that a marked increase in the pathogenicity of the donor's HIV strain(s) or a selection of a virulent strain occurred upon transfusion of his blood and this HIV strain was heterosexually transmitted by the recipients to their spouses. Another less probable explanation could be the presence of a yet unknown mechanism in the donor which repressed virus replication. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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