| Popis: |
Background: Numerous animal studies and clinical trials in cancer have shown that ibuprofen reduces the incidence of and mortality from cancer. Synthesis of novel conjugate of ibuprofen with the 2-phenyl amino pyrimidine derivative (to mimic small molecules kinase inhibitor anticancers) exhibits significant increase, as compared to free ibuprofen, potential to inhibit proliferation of cancer cells. Methods: The docking study was performed with GOLD software supplied by the Cambridge Crystallographic Data Centre. Thereafter, the chemical synthesis was established. The chemical structures of this study was confirmed by spectral instrumentation; infrared, differential scanning calorimeter thermal analyzer, proton and carbon-13 nuclear magnetic resonance. Results and Discussions: The docking process was successfully conducted and the chemical synthesis yielded a good per cent. The spectral interpretations show characteristic identification of the target chemical compound. |
