Intra-individual variation of analytes in serum from patients with chronic liver diseases

Autor:	W. G. E. Hölzel
Rok vydání:	1987
Předmět:	medicine.medical_specialty Cirrhosis biology Chemistry Biochemistry (medical) Clinical Biochemistry Albumin medicine.disease Blood proteins Endocrinology Alanine transaminase Internal medicine biology.protein medicine Alkaline phosphatase Alanine aminopeptidase Hemoglobin Gamma-glutamyltransferase
Zdroj:	Clinical Chemistry. 33:1133-1136
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/33.7.1133
Popis:	The average biological intra-individual CV in 20 patients with chronic liver diseases (CLD), estimated for 14 analytes during a stationary phase, significantly exceeded that for a normal group in the cases of Na+, K+, Cl-, total protein, albumin, cholinesterase, hemoglobin, and alpha-amylase; it did not differ significantly from the normal group for cholesterol, alkaline phosphatase, aspartate aminotransferase, and alanine aminopeptidase; and it was significantly lower than in the normal group for alanine aminotransferase and gamma-glutamyltransferase. There were no significant sex-related differences in mean intra-individual variation in CLD patients. Individual values were gaussian-distributed for all analytes, including enzymes. The estimated biological component of intra-individual variation and the analytical variation as determined for each laboratory can be used to derive decision-making criteria in monitoring CLD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::29e35eaf1d9ca6179b9987324f690539 https://doi.org/10.1093/clinchem/33.7.1133 Zobrazit plný text záznamu