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The LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus. We conducted this study to compare the efficiency of LupusQoL with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Russian patients with lupus. Both questionnaires were conducted at a single visit to the clinic. Disease activity was evaluated by the SLEDAI-2K, and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Associations between the LupusQoL and SF-36 domains were examined, while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman’s correlation coefficients, and Students t test were performed to analyze the data. A total of 328 patients with lupus (F/M 298:30, mean age 34,4±11.5 years, mean disease duration 106,3±91,9.0 months) were included, and 65,3% of these were active and 56,5% of these had SDI≥1. The mean SLEDAI 2K score was 9,6±8,0. QOL as assessed by SF-36 and LupusQoL was low in this group of patients with SLE. The mean scores for each of the domains of the LupusQoL and SF-36 are shown in table 1. The mean scores are The MCS and PCS scores were both For the 4 non-comparable domains of the LupusQoL, there was a correlation between 3 domain of LupusQoL and 1 of the component scores of SF-36: body image and SF-36 MCS, r=0.20; planning and SF-36 MCS, r=0.13, r=0.73; and burden to others and SF-36 MCS, r=0.19; body image and SF-36 PCS, r=0,38; planning and SF-36 PCS, r=0,66; and burden to others and SF-36 PCS, r=0,38. The Lupus Qol scales such as: pain, planning, intimate relationships, burden to others and bodily image correlated with disease activity (by SLEDAI 2K). Conclusions The LupusQoL-Russian is sensitive to change in SLE patients with active SLE. LupusQoL and SF-36 were equivalent in assessing the HRQOL in Russian SLE patients. Both LupusQoL and SF-36 are easily completed by patients and correlate very well with each other. The HRQOL by LupusQoL-Russian strongly correlated with disease activity. |
