Optimal tumor coverage with different beam energies by IMRT, VMAT and TOMO
Autor: | Wei Hsiu Liu, Yun Chih Chen, An Cheng Shiau, Sheng Fang Huang, Ming Hsien Li, Jang Chun Lin, Jo Ting Tsai |
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Rok vydání: | 2020 |
Předmět: |
Imrt plan
business.industry medicine.medical_treatment Cancer General Medicine medicine.disease Radiation planning Tomotherapy Radiation therapy Conformity index 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine 030212 general & internal medicine Nuclear medicine business Radiation treatment planning Left kidney |
Zdroj: | Medicine. 99:e23328 |
ISSN: | 1536-5964 0025-7974 |
DOI: | 10.1097/md.0000000000023328 |
Popis: | To compare the effects of different photon energies on radiation planning by intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and helical tomotherapy (TOMO) for proximal gastric cancer (PGC). Network analysis with microarray procession and gene ontology were used to identify the effect of radiotherapy (RT) on PGC. Then, we retrospectively analyzed 8 PGC patients after receiving irradiation with a prescribed dose of 50.4 Gy. The Pinnacle treatment planning system (TPS, V9.8) was used to generate IMRT and VMAT plans by using 6 or 10 MV. TOMO plans were calculated on the Tomotherapy Planning Station Hi-Art Version 4.2.3 workstation (Tomotherapy Incorporated, Madison, WI, USA). PGC is associated with high DNA repair ability. TOMO plan results in higher tumor coverage and a better conformity index than IMRT and VMAT. 10-MV VMAT yields better dosimetric quality of the gradient index than 6-MV VMAT (P = .012). TOMO was associated with a lower irradiation dose in the mean dose to the right kidney (P = .049), left kidney and heart than 6-MV IMRT and 6-MV VMAT. 6-MV IMRT plan presented a higher dose of lung Dmean (P = .017) than 10-MV IMRT. Additionally, VMAT, using a planning energy of 6 MV, was associated with a significantly higher left kidney Dmean (P = .018) and V10 (P = .036) than a planning energy of 10 MV. TOMO is a better RT plan not only for tumor coverage but also for sparing organs at risk. IMRT and VMAT plans with 10 MV beams are more suitable than 6 MV beams for PGC treatment. |
Databáze: | OpenAIRE |
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