ChemInform Abstract: Access to N-Thioalkenyl and N-(o-Thio)aryl-benzimidazol-2-ones by Ring Opening of Thiazolobenzimidazolium and Benzimidazobenzothiazolium Salts and C-O Bond Cleavage of an Alkoxide

Autor:	Fabien Coppola, Daniel Farran, Federico Andreoli, Nicolas Vanthuyne, Radia Kaid-Slimane, Christian Roussel
Rok vydání:	2015
Předmět:	chemistry.chemical_compound chemistry Aryl Alkoxide Rapid access Thio General Medicine Ring (chemistry) Medicinal chemistry Bond cleavage
Zdroj:	ChemInform. 46
ISSN:	0931-7597
Popis:	We report herein the synthesis of highly functionalized 1,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo[2,1-b][1,3]benzothiazol-6-ium salts and an unusual C-O bond cleavage of an alkoxide. A large variety of benzimidazolones bearing an original N-thioalkenyl or N-(o-thio)aryl group was obtained in high yields. The developed chemistry provides efficient and rapid access to the privileged benzimidazol-2-one scaffold.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::29c92fad89b61fab9c9e10da67315acd https://doi.org/10.1002/chin.201531178 Zobrazit plný text záznamu Plný text