Studies on the total synthesis of the macrolide antitumor agent rhizoxin. 1. Synthesis of the C3C13 segment

Autor:	James D. White, Neal J. Green, Christine S. Nylund
Rok vydání:	1997
Předmět:	Antitumor activity Rhizoxin Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Total synthesis Ring (chemistry) Biochemistry Combinatorial chemistry Radical cyclization chemistry.chemical_compound Pyran Drug Discovery
Zdroj:	Tetrahedron Letters. 38:7329-7332
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)01780-2
Popis:	An asymmetric synthesis of the C3C13 segment of rhizoxin is described in which the relative stereochemistry of C7 and C8 is established through a chelation-controlled allylation followed by Mitsunobu inversion, and the pyran ring is constructed by a photochemically initiated 6-exo radical cyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::29c9170d7ba8a53ff5e77047db878495 https://doi.org/10.1016/s0040-4039(97)01780-2 Zobrazit plný text záznamu Full Text from ScienceDirect