A Ratio Hypothesis Pertaining to the Biological Action of Poisons and Drugs

Autor:	J. Franklin Yeager, Sam C. Munson
Rok vydání:	1948
Předmět:	Degree of ionization Toxicology chemistry Insect Science Sodium Ionization Thermodynamics chemistry.chemical_element Working hypothesis Biology Action (physics) Interpretation (model theory)
Zdroj:	Annals of the Entomological Society of America. 41:377-383
ISSN:	1938-2901 0013-8746
DOI:	10.1093/aesa/41.3.377
Popis:	In a previous publication (3) a working hypothesis was presented to explain the relationship found to exist between the concentration of administered poison and the survival time of insects injected with sodium metarsenite. This hypothesis, which will be referred to here as the “ratio hypothesis,” was stated briefly in a generalized form and at greater length in a mathematical form. The physicochemical interpretation of the data rested upon an assumed variable ionization of the arsenite within the range of concentrations used. The purpose of the present paper is to state the generalized form of the ratio hypothesis more precisely, to distinguish between this hypothesis and any physicochemical interpretation that may be associated with it, and to accept as more likely for sodium metarsenite another tentative interpretation which is based upon degree of ionization of the arsenious acid produced by hydrolysis rather than upon degree of ionization of the sodium metarsenite.[2][1] [1]: #fn-1
Databáze:	OpenAIRE
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