Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas

Autor: Louis B. Harrison, Sanford Dubner, Elliot W. Strong, Steven I. Hajdu, Colin B. Begg, Dennis H. Kraus, Murray F. Brennan, M S Uma Kher
Rok vydání: 1994
Předmět:
Zdroj: Cancer. 74:697-702
ISSN: 1097-0142
0008-543X
Popis: Background. Soft tissue sarcomas of the head and neck represent uncommon malignant neoplasms. With the exception of orbital and parameningeal sites, the treatment of sarcomas in the head and neck has not been standardized. The authors used a prospectively collected database of adult soft tissue sarcomas to identify prognostic factors for local control and survival. Methods. A prospectively collected database of adult soft tissue sarcoma from 1982 to 1989 was analyzed for the impact of prognostic factors on local control and survival. Factors examined included histologic type, tumor grade, size, and resection margins. Results. The overall and disease free survival at 5 years was 71 and 60%, respectively. Local control was 70% at 5 years. On univariate analysis, grade and margin status were predictors for local control. Analysis based on the Cox proportional hazard model revealed that margin status was the only significant factor in predicting local control. Grade and margin status were significant prognostic indicators for survival both on univariate analysis and in the Cox proportional hazard model. Conclusion. Patients with head and neck sarcomas should undergo wide excision with the removal of all gross disease and the acquisition of negative, microscopic surgical margins. Patients with positive margins should receive adjuvant radiotherapy for local control. High grade lesions place patients at risk for local recurrence and distant dissemination. Investigational regimens designed to prevent metastatic disease should be performed. Cancer 1994; 74: 697-702.
Databáze: OpenAIRE
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