In Vivo proton spectroscopy and spectroscopic imaging of {1-13C}-g1ucose and its metabolic products

Autor:	J. Rhiz‐Cabello, Daryl Despres, Peter C.M. van Zijl, P. van Gelderen, Chrit T. W. Moonen, A. Scott Chesnick
Rok vydání:	1993
Předmět:	In situ Glutamine Crystallography Proton Heteronuclear molecule Chemistry Resolution (electron density) Analytical chemistry Radiology Nuclear Medicine and imaging Pulse sequence Sensitivity (control systems) Spectroscopy
Zdroj:	Magnetic Resonance in Medicine. 30:544-551
ISSN:	1522-2594 0740-3194
DOI:	10.1002/mrm.1910300504
Popis:	Metabolism of {1- 13 C}-glucose was studied in situ in cat brain using gradient-enhanced proton-detected heteronuclear spectroscopy. Proton detection of {1- 13 C}-glucose, {3- 13 C}lactate, 4-{ 13 C}-glutamine, 4-{ 13 C}-glutamate and the combined signals 2-{ 13 C}-glutamate/glutamine and 3-{ 13 C}-glutamate/glutamine was achieved, despite the fact that some of the associated proton resonances are close to the water signal. Two-dimensional { 1 H- 13 C}-spectra demonstrate the possibility of in situ spectral assignment with 1 H sensitivity and 13 C resolution. Spectroscopic images of glucose and its metabolic products were also acquired, showing the possibility to study spatial dependence of metabollsm
Databáze:	OpenAIRE
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