Spontaneous oscillation of the electrical membrane potential in tri-block copolypeptide membranes composed of L-glutamic acid and L-leucine

Autor:	Norihiko Minoura, Sei-ichi Aiba, Yukihiko Fujiwara
Rok vydání:	1993
Předmět:	Membrane potential Circular dichroism Oscillation Chemistry Stereochemistry Infrared spectroscopy General Chemistry Glutamic acid Biochemistry Catalysis Crystallography Hysteresis Colloid and Surface Chemistry Membrane Leucine
Zdroj:	Journal of the American Chemical Society. 115:5902-5906
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00067a002
Popis:	A membrane produced from a tri-block copolypeptide compound of poly(L-glutamic acid) as outer segments and poly(L-leucine) as an inner segment spontaneously generated electrical pulses under a concentration gradient of KCl in the absence of any external current, voltage, or pressure. At lower KCl concentrations the current-voltage curves of the membrane were sigmoidal, and hysteresis appeared. This result suggests that the membrane can have two different resistance states which are related to α-helix and random-coil conformations of the poly(L-glutamic acid) chain. According to the circular dichroism and FT-IR spectra of the membrane, in the higher resistance state the poly(L-glutamic acid) chains exhibit random-coil structure, while in the lower resistance state the chains exhibit α-helix structure
Databáze:	OpenAIRE
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