The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients
| Autor: | Karolina Dorobisz, Tomasz Zatoński, Piotr Palka, Tomasz Rutkowski, Iwona Wlodarska-Polinska, Tomasz Dworzecki, Katarzyna Pazdro-Zastawny |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry medicine.medical_treatment Head and neck cancer Neck dissection medicine.disease Tonsillectomy Radiation therapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Specimen collection Nasoendoscopy 030220 oncology & carcinogenesis medicine Carcinoma Radiology business Chemoradiotherapy |
| Zdroj: | Cancer Management and Research. 11:6603-6614 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s204346 |
| Popis: | Introduction Carcinoma of unknown primary site (CUP) refers to 1-5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx. Study objective The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients. Material and methods The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy. Conclusions Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|