Behandlung peptischer Ulzera beim Zollinger-Ellison-Syndrom mit Histamin-H2-Rezeptor-Antagonisten*1
| Autor: | Scholten T, R. Jungblut, Hausamen Tu, Fritsch Wp, Georg Strohmeyer |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Hepatitis
medicine.medical_specialty business.industry medicine.medical_treatment General Medicine Metiamide Hepatitis B medicine.disease Gastroenterology Peptic ulceration digestive system diseases chemistry.chemical_compound Basal (phylogenetics) chemistry Internal medicine medicine Gastrectomy Cimetidine business Histamine medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 102:1709-1712 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-0028-1105561 |
| Popis: | Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four patients after treatment lasting from six weeks to four-and-a-half-months. Two patients developed recurrent ulcer after the treatment had stopped, but responded to a second course. One patient developed hepatitis B during cimetidine treatment and it is possible that the course of the hepatitis was unfavourable affected by cimetidine. But no other side effects were noted nor was there a significant change in basal serum-gastrin concentration or an increase in H+ secretion. Total gastrectomy remains the treatment of choice in Zollinger-Ellison syndrome, but cimetidine should be considered if the patient refuses operation or operation is not feasible because of a poor general state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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