| Autor: |
Thiele, Maja, Hugger, Mie B, Kim, Yongsoo, Rautou, Pierre-Emmanuel, Elkrief, Laure, Jansen, Christian, Verlinden, Wim, Allegretti, Giulia, Israelsen, Mads, Stefanescu, Horia, Piscaglia, Fabio, García-Pagán, Juan C, Franque, Sven, Berzigotti, Annalisa, Castera, Laurent, Jeong, Woo K, Trebicka, Jonel, Krag, Aleksander |
| Jazyk: |
angličtina |
| Předmět: |
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| Popis: |
BACKGROUND & AIMS Liver stiffness measured with 2-dimensional shear wave elastography by Supersonic Imagine (2DSWE-SSI) is well-established for fibrosis diagnostics, but non-conclusive for portal hypertension. METHODS We performed an individual patient data meta-analysis of 2DSWE-SSI to identify clinically significant portal hypertension (CSPH), severe portal hypertension and large varices in cirrhosis patients, using hepatic venous pressure gradient and upper endoscopy as reference. We used meta-analytical integration of diagnostic accuracies with optimized rule-out (sensitivity-90%) and rule-in (specificity-90%) cut-offs. RESULTS Five studies from seven centres shared data on 519 patients. After exclusion, we included 328 patients. Eighty-nine (27%) were compensated and 286 (87%) had CSPH. 2DSWE-SSI |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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