N-aryl heterocycles via coupling reactions with arylboronic acids

Autor:	Martina Germann, Marina Lefort, Werner Mederski, Dieter Kux
Rok vydání:	1999
Předmět:	Indole test chemistry.chemical_compound medicine.drug_mechanism_of_action Chemistry Stereochemistry Aryl Organic Chemistry Drug Discovery Factor Xa Inhibitor medicine Biochemistry Coupling reaction Pyrrole
Zdroj:	Tetrahedron. 55:12757-12770
ISSN:	0040-4020
Popis:	Compounds having a partial 2-pyridone structure or 3-pyridazinones can be selectively N-arylated with phenylboronic acids according to the procedure described by Chan and Lam. This procedure leads to N5-arylated imidazo[4,5-c]pyridin-4-ones, precursors of potent factor Xa inhibitors. In addition, the synthesis of N-aryl substituted pyrrole- and indole-2-carboxylic acid esters is described. In the indole series this procedure offers a flexible entry in the synthesis of different 1,3-diaryl-2-carboxyindoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::29a556ac26797156584b87425b465be0 https://doi.org/10.1016/s0040-4020(99)00752-8 Zobrazit plný text záznamu Full Text from ScienceDirect