The Preparation of 2-Alkoxy-1,3,2-oxazaphospholidines and Some Reactions

Autor:	Yasuto Kodaira, Teruaki Mukaiyama
Rok vydání:	1966
Předmět:	chemistry.chemical_classification Tris Cyclic compound Chemistry chemistry.chemical_element General Chemistry Medicinal chemistry Sulfur Adduct chemistry.chemical_compound Yield (chemistry) Polyamide Alkoxy group Organic chemistry Alkyl
Zdroj:	Bulletin of the Chemical Society of Japan. 39:1297-1301
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.39.1297
Popis:	The preparation of 2-alkoxy-1,3,2-oxazaphospholidines and some reactions will be described. 2-Alkoxy-1,3,2-oxazaphospholidines were prepared either from ethyl phosphorodichloridite and aminoethanols or, more conveniently, from tris[diethylamino]phosphite, aminoethanols and alcohols. 2-Alkoxy-1,3,2-oxazaphospholidines reacted easily with alcohols or p-toluenesulfonic acid monohydrate to give dialkyl aminoethyl phosphites or alkyl aminoethyl phosphite by the ring-opening at the P–N linkage of the phospholidines. It was oxidized by means of sulfur or nitrogen tetroxide to give 2-thione or 2-one in high yields. Further, it was found that it reacted with ethyl isocyanate to form 1 : 1 adducts. The structure of the adducts was confirmed, by a study of its chemical transformations, to be a seven-membered cyclic compound. It also reacted with carbon dioxide at about 120°C to yield the phosphorous-containing polyamide.
Databáze:	OpenAIRE
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