Characterization of T‐ and B‐cell epitopes of a simian retrovirus (SRV‐2) envelope protein
| Autor: | L. Werner, E. Benjamini, José V. Torres, N. Pangares, C. Y. Leung, Michael K. Axthelm, Arthur Malley, S. Shiigi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
General Veterinary Peptide Biology Simian immunodeficiency virus medicine.disease_cause biology.organism_classification Virology Epitope chemistry Viral envelope Simian retrovirus biology.protein medicine Animal Science and Zoology Neutralizing antibody Peptide sequence Keyhole limpet hemocyanin |
| Zdroj: | Journal of Medical Primatology. 20:177-181 |
| ISSN: | 1600-0684 0047-2565 |
| Popis: | Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope. |
| Databáze: | OpenAIRE |
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