Influence of ultrasound on the clearance of toxic substances from Polysulfone hollow fiber membrane used in a dialyzer filter
Autor: | Vahid Zarezade, Mohammad Bagher Shiran, Naser Tabkhi, Behrouz Rasuli, Ebrahim Kalantar |
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Rok vydání: | 2018 |
Předmět: |
Chromatography
business.industry Ultrasound 02 engineering and technology 021001 nanoscience & nanotechnology Filter (aquarium) law.invention chemistry.chemical_compound 020401 chemical engineering chemistry Hollow fiber membrane law Polysulfone 0204 chemical engineering 0210 nano-technology business Filtration |
Zdroj: | Polish Journal of Medical Physics and Engineering. 24:91-97 |
ISSN: | 1898-0309 |
DOI: | 10.2478/pjmpe-2018-0012 |
Popis: | The aim of this work was to investigate the potential of high frequency ultrasound for the cleaning of a Polysulfone (PSU) ultrafiltration membrane used in hemodialysis. The blood substitute solution flowing through the hollow fiber membrane used in the High Flux F60 dialyzers has been sonicated by ultrasonic (US) waves with 1 MHz frequency and 2 W/cm2 in situ intensity. The solution was comprised of toxic compounds such as Urea, Creatinine, Vitamin B12 and Inulin. The effect of US was represented by comparison of the clearance in both OFF and ON ultrasound conditions. The results of these studies have been demonstrated that US can enhance the permeability of the PSU dialyzer membrane. Results revealed that US had significant effect (p-value ˂ 0.05) on the clearance of Inulin as a large molecule (5200 D) and accelerated its filtration by 28%. The proposed dialysis method can be used alongside the existing dialysis machine. |
Databáze: | OpenAIRE |
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